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One of Wall Street Journal’s "Best Books for Science Lovers" in 2015
Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before.
In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility.
Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging.
Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell’s ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body’s trillions of cells.
But some of our cells don’t age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young.
The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade.
The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.
- Sales Rank: #306984 in Books
- Published on: 2015-10-06
- Original language: English
- Number of items: 1
- Dimensions: 9.10" h x .90" w x 5.90" l, .0 pounds
- Binding: Hardcover
- 256 pages
Review
"The Telomerase Revolution is a remarkable book, telling a fascinating story that pulls together at last a single coherent theory of how and why growing old leads to so many different forms of illness. It also offers a tantalizing promise that we might soon know not only how to cure and prevent age-related diseases, but how to reset the aging process itself. Michael Fossel is a radical optimist."
—Matt Ridley, author of Genome and The Rational Optimist
"Telomerase Therapy breaks down centuries of human thought on aging and uproots outdated ideologies that have led to nothing but worthless snake oil products. Dr. Fossel's exciting book is opening doors to extended healthspan that can change human history, and it’s all grounded in solid scientific research."
—Noel Patton, founder and chairman of TA Sciences
"Michael Fossel’s compelling argument for the telomere approach to reversing aging isn’t just worth a look—it’s like reading the words of Virgil as he leads us along the mysteries of aging."
—Alexey Olovnikov, PhD, Institute of Biochemical Physics and Russian Academy of Sciences
“Aging is not an irreversible degenerative process, but an epigenetically determined physiological mechanism, which must not be confused with age-related diseases caused by lifestyle choices. Here, we have an effective and clear guide to understand how we get old and how to tame aging in a few years.”
—Giacinto Libertini, MD, member of the Italian Society of Evolutionary Biology
"As a follow-up to his previous publications on the subject, Dr. Fossel brings the reader up-to-date on the progress made in understanding the central role of the telomere in aging. . . . Although a couple of decades of effort have ensued and candidate interventions have emerged, there are no strong and clinically proven interventions at the fore; however, Dr. Fossel constructs a very optimistic but realistic view of what may be on horizon to create the Telomerase Revolution."
—Donald K. Ingram, PhD, professor at the Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center
About the Author
Dr. Michael Fossel earned both his PhD and MD from Stanford University, where he taught neurobiology and research methods. Winner of a National Science Foundation fellowship, he was a clinical professor of medicine for almost three decades, the executive director of the American Aging Association, and the founding editor of Rejuvenation Research. In 1996, he wrote the first book on the telomerase theory of aging, Reversing Human Aging, describing the medical aspects of extending human telomeres, reversing aging, and curing age-related disease. In 2004, he authored the magisterial academic textbook, Cells, Aging, and Human Disease, and in 2011, he coauthored The Immortality Edge, a bestselling discussion of the potential for extending the human lifespan. He currently teaches The Biology of Aging at Grand Valley State University.
The world's foremost expert on the clinical use of telomerase for age-related diseases, Michael has lectured at the National Institute for Health and the Smithsonian Institute, and continues to lecture at universities, institutes, and conferences throughout the world. He has appeared on Good Morning America, ABC 20/20, NBC Extra, Fox Network, CNN, BBC, Discovery Channel, and regularly on NPR. He is currently working to bring telomerase to human trials for Alzheimer’s disease.
Most helpful customer reviews
26 of 26 people found the following review helpful.
Get excited about this!
By Gerald Broussard
As an aging physician(ophthalmologist) who has been interested in aging, that is, how to delay it, and if possible reverse it, I have studied every claim to these ends and indulged in the few which seemed reasonable. Dr. Fossel, who has written the only medical textbook on cellular aging in existence, explains how telomere loss leads to increasing cellular senescence and eventual death,with the subsequent death of the organism. He cites some lower organisms which never die until eaten because telomeres are maintained. Most significantly, he explains how activation of the dormant gene in our cells for the enzyme which builds telomeres will reverse cellular aging, and therefore prevent a host of degenerate diseases. It has already been done in the lab on tissues and even in some artificially aged lower animals.
This book is written for educated laymen as well as physicians. It is to the point, logical, and In my opinion compelling. Very well written. The explanation on how telomere loss leads to specific diseases alone is worth the read. There is even a reasonable speculation of why evolution would 'select' death for all of us individual organisms.
This is something to get excited about! It looks like the 'real McCoy' of age reversal! Read it and gain hope!
14 of 15 people found the following review helpful.
Very readable and critical work that will impact us as well as our society in a surprisingly near future.
By Bradley C. Edwards
Let me preface my remarks by saying I have a Ph.D. in physics and have been working in research for 25 years. I am skeptical of most things and objective to the point where it bugs my family. Now.... I was lucky enough to grab one of the first copies of this book. I have already read it and loaned it to my uncle. Dr. Fossel has been working in this area for 30 years and knows it forward and backward. What he covers in here is outstanding and surprising! Surprising because the science is straightforward, the implications staggering and the media, governments and society in general aren't going nuts over it. The problem is that we have all heard the snake oil claims for herbs, suppliments, ... that will cure us of everything and make us kids again. Those claims have jaded us. Then comes this book on the basic science of what is happening and no sales pitch. This is the book to read to understand why we age and what it means. Someday maybe this will turn into a fountain of youth drug but for now this book is real, objective information on aging and how it affects us all. If you have an interest in why we age but aren't up for technical journal articles then this is the book for you.
10 of 10 people found the following review helpful.
A real near revolution
By Libertini Giacinto
Today aging is interpreted in two very different ways with many opposing assumptions and implications. The old paradigm defines aging as the cumulative effect of various inevitable degenerative processes that can be mitigated but never completely controlled. The new paradigm considers aging as a physiological phenomenon with specific mechanisms genetically determined and regulated. This, in principle, allows to consider methods that might control aging even completely.
The book by Michael Fossel, The Telomerase Revolution (BenBella Books, 2015), is clearly on the side of the new paradigm. The book traces, in a simplified way but with many enrichments, the concepts expounded in the well-known authoritative and documented textbook by the same author [1]. It describes, in a popular way, how we age through mechanisms based on the telomere-telomerase system and the consequent progressive decrease both of cell turnover and of cell efficiency.
In the arguments of the book, there is also a net distinction between aging and the common diseases caused by wrong lifestyles whose effects increase in proportion to age. While these diseases can be prevented by avoiding incorrect lifestyles, the same measures are totally ineffective to slow down aging. It is also true, however, that erroneous lifestyles both cause distinct diseases and accelerate and complicate aging effects, a common cause of confusion between aging and age-related diseases.
Fossel's description of aging mechanisms is linear and consistent and should allow the understanding of complex concepts – some of them in contrast with widespread and accepted ideas - even to those who are not biology scholars or are unfamiliar with the medical or scientific world.
Also, and this is the aspect that will be the most attractive for a much wider audience of readers, it opens the discussion – not in charlatan but in real terms! - on how it would be possible to stop or reverse the process of aging.
Since 1998, it is well known how to reverse completely aging at the cellular level by well-known experiments of telomerase activation [2-4]. Similar experiments in the whole animal are few but extremely promising [5, 6]. The author highlights how a factor that thwarts further progress on this way is an unreasonable or at least exaggerated fear that telomerase activation procedures are carcinogenic. This fear arises from the consideration that, for the old paradigm, mechanisms genetically regulated that determine aging are impossible. Consequently, the sophisticated mechanism, based on the telomere-telomerase system, which regulates and limits progressively cell replication and efficiency, must have some justification. The only explanation that has been proposed is that such a mechanism is a general defense against cancer and so the reactivation of telomerase would alter an essential defense. This erroneous and untenable explanation [7] is openly opposed by the author who, instead, to counter aging, proposes drugs or genetic interventions for the stimulation or reactivation of telomerase.
The book, is challenging and breaks old patterns built on paradigms that appear more and more inconsistent and wrong. To define the author a heretic is a compliment addressed to him, who, besides, is fully aware of this, as it is showed by a dedication formulated in his main work: "Great ideas Janus'd pivot on the cusp of history: they are looking forward obviously foolish, looking backwards they appear foolishly obvious. We are doubly blind." [1]
In this positive critique of the book, however, it is necessary to specify what I consider its main limit.
The text does not expound or explore a series of experimental evidence and theoretical arguments that are against the old paradigm and in support of the new [8]. The author understands and explains beautifully aging mechanisms, but the evolutionary roots of the phenomenon and its necessary framework in the broad category of phenoptosis (sacrifice of an individual on the basis of supra-individual selective mechanisms) [9] are not within its investigation or familiarity. Maybe this would have increased the difficulty of reading for a non-specialist reader and increased the opposition and the criticisms of those who are anchored to the old paradigm.
Other minor criticisms are possible but they are of little importance for the meaning and the overall value of the book that is to disseminate and support disruptive ideas supported by known empirical data: another step in a scientific revolution in action, with wide consequences for our future.
In short, this is a book that should be read and meditated.
Giacinto Libertini (MD, Independent Researcher, Member of the Italian Society of Evolutionary Biology)
[1] Fossel M. Cells, Aging an Human Disease, Oxford University Press, 2004.
[2] Bodnar AG, Ouellette M, Frolkis M, et al. Extension of Life-Span by Introduction of Telomerase into Normal Human Cells. Science 1998; 279:349-52.
[3] Counter CM, Hahn WC, Wei W, et al. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci USA 1998; 95:14723-8.
[4] Vaziri H, Benchimol S. Reconstitution of telomerase activity in normal cells leads to elongation of telomeres and extended replicative life span. Curr Biol 1998; 8:279-82.
[5] Jaskelioff M, Muller FL, Paik JH, et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 2011; 469:102-6.
[6] de Jesus BB, Vera E, Schneeberger K, et al. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med 2012; 4:1-14.
[7] Libertini G. Evidence for aging theories from the study of a hunter-gatherer people (Ache of Paraguay). Biochem (Mosc) 2013; 78(9):1306-17.
[8] Libertini G. Non-programmed Versus Programmed Aging Paradigm. Curr Aging Sci 2015; 8:55-68.
[9] Libertini G. Classification of Phenoptotic Phenomena. Biochem (Mosc) 2012; 77(7):847-57.
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